Sains Malaysiana 52(6)(2023): 1749-1758
http://doi.org/10.17576/jsm-2023-5206-11
Insights
on Anticancer Activities, Associated Phytochemicals and Potential Molecular
Mechanisms of Quisqualis indica: A Mini Review
(Pandangan tentang Aktiviti Antikanser, Fitokimia Berkaitan dan Mekanisme Molekul Berpotensi Quisqualis indica: Suatu Kajian Mini)
YUAN SENG
WU1,2, MICHELLE FELICIA LEE1,2, RHANYE MAC GUAD3,*, FATHIMA
ZAHRAA OZEER1,2, APPALARAJU VELAGA4, VETRISELVAN
SUBRAMANIYAN5,6, NEERAJ KUMAR FULORIA7, SHIVKANYA FULORIA7,
KER WOON CHOY8, SZE MENG LEE4, SUBASH C.B. GOPINATH9,10,
AMITA VERMA11 & TZE PHENG LAU2
1Centre for Virus and
Vaccine Research, School of Medical and Life Sciences,
Sunway University, 47500 Petaling Jaya, Selangor, Malaysia
2Department of Biological
Sciences, School of Medical and Life Sciences, Sunway University, 47500 Petaling Jaya, Selangor, Malaysia
3Department of Biomedical
Science and Therapeutics, Faculty of Medicine and Health Science, Universiti Malaysia Sabah, 88400 Kota Kinabalu,
Sabah, Malaysia
4Department of Medicinal
Chemistry, Faculty of Pharmacy, MAHSA University, 42610 Jenjarom,
Selangor, Malaysia
5Jeffrey Cheah School of Medicine and Health Sciences, Monash
University Malaysia, Bandar Sunway, 47500 Subang Jaya, Selangor, Malaysia
6Center for
Transdisciplinary Research, Department of Pharmacology, Saveetha Institute of Medical and Technical Sciences, Saveetha Dental College and Hospital, Saveetha University,
Chennai, Tamil Nadu, 600077, India
7Faculty of Pharmacy,
AIMST University, 08100 Bedong, Kedah, Malaysia
8Department of Anatomy,
Faculty of Medicine, Universiti Teknologi MARA, 47000 Sungai Buloh, Selangor, Malaysia
9School of Bioprocess
Engineering, Universiti Malaysia Perlis, 02600 Arau,
Perlis, Malaysia
10Institute of Nano Electronic
Engineering, Universiti Malaysia Perlis, 01000 Kangar, Perlis, Malaysia
11Department of
Pharmaceutical Sciences, Sam Higginbottom University
of Agriculture, Technology and Sciences, Prayagraj,
India
Received: 13 December
2022/Accepted: 12 June 2023
Abstract
Drug resistance is the main issue causing the
treatment failure of anticancer drugs. This issue has urged researchers to
search for new substances from medicinal plants, which are widely reported as
the good sources of anticancer agents. Quisqualis indica is a
plant belongs to Combretaceae family, known as
Rangoon Creeper, which can be found abundantly in tropical countries and
distributed profusely as a wild shrub. It has been widely used traditionally
and scientifically claimed to process various therapeutic activities. It has
recently been reported to possess various potential anticancer activities
against different cancers. Looking at its availability in almost all seasons
and grow fast, it is an arising source of herbal medicine in the discovery of
anticancer drugs economically. Besides, Q. indica is enriched with several secondary
metabolites of interest, which are responsible for the positive findings for
its anticancer potentials. In this review, we aim to decipher and discuss the
anticancer activities of Q. indica crude
extracts and isolated phytochemicals as evidenced in preclinical models, as
well as the associated molecular mechanisms. More preclinical investigations on
its anticancer potentials should be conducted before translation to clinical
testing.
Keywords:
Anticancer; molecular mechanism; phytochemicals; phytotherapy; Quisqualis indica
Abstrak
Rintangan ubat adalah isu utama yang menyebabkan kegagalan rawatan ubat antikanser sintetik. Isu ini telah menggesa para penyelidik untuk mencari bahan baharu daripada tumbuhan ubatan yang dilaporkan secara meluas sebagai sumber agen antikanser yang baik. Quisqualis indica ialah tumbuhan daripada famili Combretaceae dan dikenali sebagai Rangoon Creeper. Ia mudah ditemui di negara tropika dan bertaburan dengan banyak sebagai semak liar. Q. indica telah digunakan dengan meluas secara tradisi dan dibuktikan secara saintifik mempunyai pelbagai aktiviti terapeutik. Ia telah dilaporkan menunjukkan pelbagai aktiviti antikanser yang berpotensi terhadap pelbagai kanser. Melihat pada ketersediaannya dalam hampir semua musim dan berkembang pesat, ia merupakan sumber perubatan herba ekonomi dalam penemuan ubat-ubatan antikanser. Selain itu, Q. indica diperkaya dengan beberapa metabolit sekunder yang diminati dan bertanggungjawab terhadap penemuan positif potensi antikansernya. Ulasan ini bertujuan untuk menguraikan dan membincangkan aktiviti antikanser ekstrak mentah Q. indica dan fitokimia terpencil seperti yang dibuktikan dalam model praklinikal dan mekanisme molekul yang berkaitan. Penyelidikan masa depan boleh meliputi lebih banyak ujian praklinikal untuk lebih mengenai potensi antikansernya sebelum terjemahan kepada ujian klinikal.
Kata kunci: Antikanser; fitokimia; fitoterapi; mekanisme molekul; Quisqualis indica
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*Corresponding
author; email: rhanye@ums.edu.my
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