Sains Malaysiana 52(6)(2023): 1785-1794
http://doi.org/10.17576/jsm-2023-5206-14
A Systematic Review of the Clinical
Effectiveness of Aloe vera for the Prevention and Treatment of Chronic Wounds
(Suatu Ulasan Sistematik Keberkesanan Klinikal Aloe vera untuk Pencegahan dan Rawatan Luka Kronik)
AHMAD
NUR AFIEQ IDRUS1, KHURRAM REHMAN2 & MOHD HANIF
ZULFAKAR1,3,*
1Faculty of Pharmacy, Universiti Kebangsaan Malaysia, Jalan Raja Muda Abdul Aziz, 50300 Kuala Lumpur, Malaysia
2Department of Pharmacy,
Forman Christian College, Ferozpur Road, 54600,
Lahore, Pakistan
3Centre for Drug Delivery Technology, Faculty of
Pharmacy, Universiti Kebangsaan Malaysia, Jalan Raja Muda Abdul Aziz, 50300 Kuala Lumpur, Malaysia
Received: 25 February 2023/Accepted: 12 June 2023
Abstract
Aloe vera is an herbaceous and perennial plant
that belongs to Liliaceae family and used for
many medicinal purposes. Aloe vera have been
associated with the treatment of skin burns and postoperative wound healing but
not many clinical studies have been conducted to evaluate its effectiveness
against chronic wounds such as pressure injury. The present study aimed to
systematically review clinical trials investigating the effect of Aloe vera on the prevention and healing of chronic wounds. To identify all related published
studies, Science Direct, Google Scholar, PubMed, and Ovid MEDLINE databases
were searched in English language from the year 2015-2022. All clinical trials
using Aloe vera gel, cream, or derivatives that
included a control group with placebo or comparison with other treatments were
included in the study according to the PRISMA selection process. In total, 11
trials that met the inclusion criteria were reviewed. The results of the
studies showed successful use of Aloe vera in the
prevention and treatment of chronic wounds including pressure injuries, chronic
wound ulcers, diabetic foot ulcers, chronic anal fissures, and traumatic oral
ulceration due to orthodontic appliances. Based on its safety and efficacy
profile, this review concluded that Aloe verahas
potential benefits to be used as a complementary or alternative treatment in
chronic wounds along with conventional methods. Its ability to retain skin
moisture and preservation of skin integrity supports its use in the prevention
of ulcers.
Keywords: Aloe vera; chronic wound; clinical
trial; wound prevention; wound treatment
Abstrak
Aloe vera adalah tumbuhan
herba dan saka yang tergolong dalam famili Liliaceae dan banyak digunakan
untuk tujuan perubatan. Aloe vera telah dikaitkan dengan rawatan kulit melecur
dan penyembuhan luka selepas pembedahan tetapi tidak banyak kajian klinikal
yang dijalankan untuk menilai keberkesanannya terhadap luka kronik seperti
kecederaan tekanan. Kajian ini bertujuan untuk menilai secara sistematik ujian
klinikal yang mengkaji kesan Aloe vera terhadap pencegahan dan penyembuhan luka
kronik. Untuk mengenal pasti semua kajian berkaitan yang telah diterbitkan,
artikel dalam bahasa Inggeris dari tahun 2015-2022 telah dicari di pangkalan
data Science Direct, Google Scholar, PubMed dan Ovid MEDLINE. Semua ujian
klinikal menggunakan gel Aloe vera, krim atau derivatif yang turut melibatkan
kumpulan kawalan dengan plasebo atau perbandingan dengan rawatan lain
dimasukkan ke dalam kajian mengikut proses pemilihan PRISMA. Eja ujian yang
memenuhi kriteria kemasukan telah disemak. Hasil kajian menunjukkan
keberkesanan penggunaan Aloe vera dalam pencegahan dan rawatan luka kronik
termasuk kecederaan tekanan, ulser luka kronik, ulser kaki diabetik, fisur
dubur kronik dan ulser mulut traumatik akibat peralatan ortodontik. Kajian ini
menyimpulkan bahawa Aloe vera mempunyai potensi untuk digunakan sebagai
pelengkap atau rawatan alternatif dalam luka kronik bersama-sama dengan kaedah
konvensional. Keupayaannya untuk mengekalkan kelembapan kulit dan pemeliharaan
integriti kulit menyokong penggunaannya dalam pencegahan ulser.
Kata kunci: Aloe vera;
luka kronik; pencegahan luka; rawatan luka; ujian klinikal
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*Corresponding author; email: hanifzulfakar@ukm.edu.my
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