Sains Malaysiana
50(1)(2021): 207-226
http://dx.doi.org/10.17576/jsm-2021-5001-21
Annexin A1 (ANXA1): A Systematic Review of
Its Role in Inflammation
(Aneksin A1 (ANXA1): Suatu Ulasan Sistematik tentang
Peranannya dalam Keradangan)
SANGGAVI
NADARAJAN, NORAZRINA AZMI, MALINA JASAMAI & ENDANG KUMOLOSASI*
Drug and Herbal Research Centre, Faculty of Pharmacy, Universiti
Kebangsaan Malaysia, 50300 Kuala Lumpur, Federal Territory, Malaysia
Diserahkan: 23 April 2020/Diterima: 1 Julai
2020
ABSTRACT
Inflammation is a body response towards any injury
or tissue damage. It involves the accumulation of neutrophils and release of
inflammatory mediators. ANXA1, a 37 kDa glucocorticoid inducible protein plays an
important role in resolving inflammation. The unique N-terminal and its mimetic
peptide exert strong anti-inflammatory actions. This study was conducted to
review the roles of ANXA1 in inflammation and identify any other reported
roles. Electronic search was done whereby a total of 3797 articles were located
from three databases, namely Ovid MEDLINE, Science Direct, and PubMed. Articles
on ANXA1 and inflammation were selected based on inclusive criteria and review
papers were excluded. Bias analysis was performed based on bias risk tool and
27 articles were included in the study. It was found that ANXA1 was able to
resolve inflammation in many inflammatory diseases. Upon treatment with
glucocorticoid, ANXA1 is induced and its significant expressions in tissues are
important in resolving inflammation. However, this effect can be reversed by
administering an anti-annexin antibody. This protein also acts on members of
all formyl peptide receptors (FPR) and activates them to initiate reaction. It
acts mainly by causing the death of neutrophils through apoptosis. In addition,
ANXA1 is identified as a marker in cancer cells which determines the survival
rates. In conclusion, ANXA1 is a key modulator in resolving inflammation in
many diseases and is actively being induced upon glucocorticoid treatment.
Keywords: Annexin A1; Annexin 1; ANXA1; inflammation; Lipocortin-1; phospholipase
A2 inhibitory protein
ABSTRAK
Keradangan adalah tindak balas badan terhadap
sebarang kecederaan atau kerosakan tisu. Ia melibatkan pengumpulan neutrofil
dan pembebasan perantara keradangan. ANXA1, sejenis protein yang boleh diaruh
glukokortikoid 37 kDa memainkan peranan penting dalam menangani keradangan.
Terminal-N yang unik dan peptida mimetiknya menunjukkan tindakan anti-keradangan
yang kuat. Kajian ini dijalankan untuk mengkaji peranan ANXA1 dalam keradangan
dan mengenal pasti lain-lain peranan yang dilaporkan. Pencarian elektronik
dilakukan dan sejumlah 3797 artikel diperoleh daripada tiga pangkalan data
iaitu Ovid MEDLINE, Science Direct dan PubMed. Artikel mengenai ANXA1 dan
keradangan dipilih berdasarkan kriteria inklusif dan tidak termasuk artikel
ulasan. Analisis pincang dilakukan berdasarkan peralatan risiko pincang dan 27
artikel dimasukkan dalam kajian. Didapati bahawa ANXA1 dapat menangani
keradangan dalam pelbagai penyakit radang. Semasa rawatan menggunakan
glukokortikoid, ANXA1 diaruh dan ekspresi ketaranya dalam tisu adalah penting
dalam menangani keradangan. Walau bagaimanapun, kesan ini dapat dibalikkan
dengan menggunakan antibodi anti-aneksin. Protein ini juga didapati bertindak
pada semua jenis reseptor peptida formil (FPR) dan mengaktifkannya untuk
memulakan tindak balas. Ia bertindak terutamanya dengan menyebabkan kematian
neutrofil melalui apoptosis. Sebagai tambahan, ANXA1 dikenal pasti sebagai
penanda sel barah yang menentukan kadar kemandirian. Kesimpulannya, ANXA1
adalah modulator utama dalam menangani keradangan dalam pelbagai penyakit dan
secara aktif diaruh oleh rawatan glukokortikoid.
Kata kunci: Aneksin
A1; Aneksin 1; ANXA1; inflamasi; Lipokortin-1; protein penyekat fosfolipase A2
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*Pengarang untuk
surat-menyurat; email: e_kumolosasi@ukm.edu.my
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