Sains Malaysiana 48(6)(2019): 1301–1310
http://dx.doi.org/10.17576/jsm-2019-4806-19
Recent Progress on
Fabrication of Zinc Oxide Nanorod-Based Field Effect Transistor Biosensors
(Kemajuan Terkini Fabrikasi
Biosensor Berasaskan Nanorod Kesan Medan Transistor Zink Oksida)
SITI SHAFURA A KARIM, CHANG-FU DEE, BURHANUDDIN YEOP MAJLIS
& MOHD AMBRI MOHAMED*
Institute of
Microengineering and Nanoelectronics (IMEN), Universiti Kebangsaan Malaysia,43600
UKM Bangi, Selangor Darul Ehsan, Malaysia
Diserahkan: 20 Februari
2019/Diterima: 19 Mac 2019
ABSTRACT
Zinc oxide is a unique
n-type semiconducting material, owing to wide bandgap of ~3.37 eV, non-toxic,
bio-safe and biocompatible with high isoelectric point of ~9.5, make it as
promising biomaterial to be utilized as sensing matrix in biosensor
applications. In addition, ZnO that possess high electron affinity provide a
good conduction pathway for the electrons hence result in significant
electrical signal change upon detection to target biomolecules. Moreover, high
surface area of ZnO nanorod enhance immobilization of enzymes, hence, increase
the device performance. Field effect transistor (FET)-based
biosensor offer simplicity in handling and label-free, has also become research
topic among researchers for novel biosensor development. This review aims to
explore the preparation of ZnO nanorod using hydrothermal method and
investigate the fabrication of ZnO nanorod-based FET biosensor.
Thus, contribute to enhance understanding towards biosensor development for
health monitoring, especially based on FETs structure devices.
Keywords: Biosensor;
field effect transistor; hydrothermal method; zinc oxide nanorod
ABSTRAK
Zink oksida adalah bahan
semikonduktor jenis-n yang unik, disebabkan oleh ketinggian selebar
~3.37 eV, tidak toksik, selamat dan bioserasi dengan titik isoelektrik
yang tinggi ~9.5, menjadikan ia sebagai biobahan yang sesuai digunakan
sebagai matriks penderia dalam aplikasi biosensor. Di samping itu,
ZnO yang mempunyai keafinan elektron yang tinggi memberikan laluan
konduksi yang baik untuk elektron dan mengakibatkan perubahan isyarat
elektrik yang signifikan apabila pengesanan kepada biomolekul sasaran.
Tambahan pula, kawasan permukaan ZnO nanorod yang tinggi meningkatkan
immobilisasi enzim, seterusnya meningkatkan prestasi peranti. Biosensor
berasaskan kesan medan transistor (FET)
adalah mudah dikendalikan dan bebas label, juga menjadi topik penyelidikan
dalam kalangan penyelidik untuk pembangunan biosensor yang novel.
Kajian ini bertujuan untuk meneroka penyediaan ZnO nanorod menggunakan
kaedah hidroterma dan mengkaji fabrikasi biosensor FET yang berasaskan ZnO nanorod.
Sekaligus menyumbang kepada kefahaman tentang pembangunan biosensor
untuk memantau kesihatan, terutamanya yang berasaskan struktur FETs.
Kata kunci: Biosensor; kaedah hidroterma; kesan medan transistor;
zink oksida nanorod
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*Pengarang
untuk surat-menyurat; email: ambri@ukm.edu.my
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