Sains Malaysiana 48(6)(2019): 1259–1265

http://dx.doi.org/10.17576/jsm-2019-4806-13

Refractive Index and Sensing of Glucose Molarities determined using Au-Cr K-SPR at 670/785 nm Wavelength

(Indeks Biasan dan Pengesanan Kemolaran Glukosa melalui Au-Cr K-SPR pada Panjang Gelombang 670/785 nm)

P. SUSTHITHA MENON¹*, BUDI MULYANTI², NUR AKMAR JAMIL¹, CHANDRA WULANDARI³, HARBI SETYO NUGROHO³, GAN SIEW MEI¹, NOOR FAIZAH ZAINUL ABIDIN¹, LILIK HASANAH³, ROER EKA PAWINANTO² & DILLA DURYHA BERHANUDDIN¹

¹Institute of Microengineering and Nanoelectronics (IMEN), Universiti Kebangsaan Malaysia, 43600 UKM Bangi, Selangor Darul Ehsan, Malaysia

²Department of Electrical Engineering Education, Universitas Pendidikan Indonesia (UPI), Bandung 40154 Jawa Barat, Indonesia

³Department of Physics Education, Universitas Pendidikan Indonesia (UPI), Bandung 40154 Jawa Barat, Indonesia

Diserahkan: 2 Januari 2019/Diterima: 28 Februari 2019

ABSTRACT

In this paper, we determine the optical refractive indices of different molarities of glucose using nano-laminated gold/chromium (Au-Cr) thin film via Kretschmann-based Surface Plasmon Resonance (K-SPR) sensing with angular interrogation. The nano-laminated Au-Cr K-SPR sensor detects the glucose presence in low- and high-concentration of 4-12 mmol/L and 55-277 mmol/L, respectively, under the exposure of 670 nm and 785 nm optical wavelengths. The experimental results showed that the minimum limit of detection (LOD) of Au-Cr K-SPR is 4 mmol/L and the glucose sensor sensitivities are in average of 3.41 o/M and 2.73o/M at 670 nm and 785 nm optical wavelength, respectively. Stable sensitivity for each concentration also shown from the sensorgram results, indicates the stable performance of nano-laminated Au-Cr SPR sensor to detect glucose in the range from mmol/L up to dmol/L. Values of refractive indices for glucose molarities obtained are 1.33187 (4 mmol/L) and 1.3191 (4 mmol/L) at 670 and 785 nm wavelength, respectively. These RI values are beneficial for numerical simulation of glucose sensors using nano-laminated Au-Cr thin films which have been reported for the first time. The sensor can be eventually deployed in integrated photonic sensing devices comprising of multiple analyte detection for lab-on-chip (LoC) and point-of care (PoC) applications.

Keywords: Angular interrogation; glucose sensor; gold/chromium; Kretschmann; nano-laminated; refractive index; surface plasmon resonance

ABSTRAK

Dalam kajian ini, indeks biasan optik daripada kemolaran glukosa yang berbeza ditentukan dengan menggunakan filem nipis nano emas/kromium (Au-Cr) melalui sensor resonan plasmon permukaan berasaskan konfigurasi Kretschmann (K-SPR) dengan interogasi sudut. Sensor Au-Cr K-SPR berlapis nano mengesan kehadiran glukosa dalam kepekatan rendah dan tinggi iaitu 4-12 mmol/L dan 55-277 mmol/L masing-masing di bawah pendedahan panjang gelombang optik 670 nm dan 785 nm. Keputusan uji kaji menunjukkan bahawa had minimum pengesanan (LOD) Au-Cr K-SPR adalah 4 mmol/L dan kepekaan sensor glukosa adalah secara purata sebanyak 3.41°/M dan 2.73°/M, masing-masing pada panjang gelombang 670 nm dan 785 nm. Pengesanan yang stabil daripada sensorgram untuk setiap kepekatan glukosa menunjukkan prestasi sensor Au-Cr SPR nano-lamina untuk mengesan glukosa dalam lingkungan dari mmol/L sehingga dmol/L. Nilai indeks biasan (RI) untuk kemolaran glukosa yang diperoleh ialah 1.33187 (4 mmol/L) dan 1.3191 (4 mmol/L) pada panjang gelombang 670 dan 785 nm. Nilai RI ini bermanfaat untuk simulasi berangka sensor glukosa menggunakan filem tipis nano-lamina Au-Cr yang dilaporkan buat pertama kali. Sensor ini akhirnya boleh digunakan dalam peranti terintegrasi fotonik yang bersepadu yang terdiri daripada pelbagai pengesanan analit untuk aplikasi makmal-atas-cip (LoC) dan point-of care (PoC).

Kata kunci: Emas/kromium; indeks biasan; interograsi sudut; konfigurasi Kretschmann; nano-lamina; resonan plasmon permukaan; sensor glukosa

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*Pengarang untuk surat-menyurat; email: susi@ukm.edu.my