Sains Malaysiana 44(8)(2015): 1125–1128

The Chemical Constituents of Ellipeia cuneifolia and Their Antibacterial Activity

(Komposisi Kimia daripada Ellipeia cuneifolia dan Aktiviti Antibakterianya)

HASLIZA YUSOF¹, LAILY B. DIN¹, WAN A. YAACOB¹*, NAZLINA IBRAHIM²,

BOHARI M. YAMIN¹ & A. LATIFF³

¹School of Chemical Sciences and Food Technology, Faculty of Science and Technology

Universiti Kebangsaan Malaysia, 43600 Bangi, Selangor D.E. Malaysia

²School of Biosciences and Biotechnology, Faculty of Science and Technology, Universiti Kebangsaan Malaysia, 43600 Bangi, Selangor D.E. Malaysia

³School of Environmental and Natural Resource Sciences, Faculty of Science and Technology

Universiti Kebangsaan Malaysia, 43600 Bangi, Selangor D.E., Malaysia

Diserahkan: 6 Oktober 2014/Diterima: 9 April 2015

ABSTRACT

Chromatographic purification of chloroform extract of the twigs of Ellipeia cuneifolia has led to the discovery of three compounds comprising of 2’,4’-dihydroxy-4,6’-dimethoxychalcone; tepanone; and O-methylmoschatoline. Structures of the compounds were established by interpreting their spectral data and by comparing them with those of the literature. Two of them showed antibacterial activities.

Keywords: Annonaceae; antibacterial activity; chalcone; Ellipeia cuneifolia; oxoaporphine; retrochalcone; twig

ABSTRAK

Penulenan kromatografi terhadap ekstrak kloroform ranting Ellipeia cuneifolia membawa kepada penemuan 3 sebatian iaitu 2’,4’-dihidroksi-4,6’-dimetoksikalkon; tepanon; dan O-metilmoskatolina. Struktur sebatian ini telah ditentukan dengan mentafsirkan data spektrum dan membandingkannya dengan data spektrum daripada penerbitan. Dua daripadanya menunjukkan aktiviti antibakteria.

Kata kunci:  Aktiviti antibakteria; Annonaceae; Ellipeia cuneifolia; kalkon; oksoaporfina; ranting; retrokalkon

RUJUKAN

Colegate, S.M., Din, L.B., Ghisalberti, E.L. & Latiff, A. 1992. Tepanone, a retrochalcone from Ellipeia cuneifolia. Phytochemistry 31: 2123-2126.

Kessler, P.J.A. 1993. Annonaceae. In The Families and Genera of Vascular Plants. Volume II. Flowering Plants. Dicotyledons: MagnoliidHamamelid and Caryophyllid Families, edited by Kubitzki, K., Rohwer, J.G. & Bittrich, V. Berlin: Springer- Verlag. pp. 93-129.

Ridley, H.N. 1922. The flora of the Malay Peninsula. Vol II. Reprinted 1967. London: L. Reeve & Co.

Seidel, V., Bailleul, F. & Waterman, P.G. 2000. (Rel)- 1β,2α-di-(2,4-dihydroxy-6-methoxybenzoyl)-3β,4α-di-(4- methoxyphenyl)-cyclobutane and other flavonoids from the aerial parts of Goniothalamus gardneri and Goniothalamus thwaitesii. Phytochemistry 55: 439-446.

Sinclair, J. 1955. A revision of the Malayan Annonaceae. Gardens’ Bulletin Singapore 14(2): 149-516.

Wijeratne, E.M.K., Hatanaka, Y., Kikuchi, T., Tezuka, Y. & Gunatilaka, A.A.L. 1996. A dioxoapophine and other alkaloids of two Annonaceous plants of Sri Lanka. Phytochemistry 42: 1703-1706.

Zawawi, N.K.N.A., Ahmat, N., Ahmad, R., Jaafar, F.M. & Ghani, N.A. 2012. Oxoaporphine alkaloids and flavonols from Xylopia ferruginea (Annonaceae). Biochemical Systematics and Ecology 43: 7-9.

*Pengarang untuk surat-menyurat; email: wanyaa@ukm.edu.my