Sains Malaysiana 42(3)(2013):
365–371
Association
of Fat Mass and Obesity-associated (FTO) Gene rs9939609 Variant with Obesity
Among Multi-ethnic Malaysians in Kampar, Perak
(Kaitan Gen Jisim Lemak dan Berkaitan
Obesiti (FTO)
Polimorfisma rs9939609 dengan
Obesiti dalam Masyarakat Berbilang Etnik
Malaysia di Kampar, Perak)
Wei-Wei Chey, Sook-H aFan& Yee-H owSay*
Department of Biomedical
Science, Faculty of Science, Universiti Tunku Abdul Rahman (UTAR) Perak Campus,
31900 Kampar, Perak, Malaysia
Diserahkan: 26 Mei 2011/Diterima:
15 Oktober 2012
ABSTRACT
Obesity is a multifactorial disease
caused by the interaction of genetic, lifestyle and environmental factors.
Common single nucleotide polymorphisms in the recently-described Fat Mass and
Obesity-Associated (FTO)
gene have been related to body weight and fat mass in humans and genome-wide
association studies in several populations have indicated that the FTO rs9939609 variant is
associated with obesity. Therefore, the objective of this study was to
investigate the association of the FTO rs9939609
variant with obesity among 324 multi-ethnic Malaysians (98 Malays, 158 Chinese,
68 Indians) who attended the Kampar Health Clinic, Perak. With the overall
minor A allele frequency (MAF)
of 0.199, the distribution of genotypes and alleles was significantly different
among ethnicities (MAF highest
among Malays), but no association was found for obesity, related anthropometric
measurements and gender. Subject with allele A had marginally but significantly
higher waist circumference (p=0.015), thus the FTO rs9939609 allele was associated with central obesity (p=0.034 by
Chi-square analysis; Odds Ratio (OR)=1.680
(CI=1.036, 2.724; p=0.035)).
However, this association was abolished when adjusted for age, gender and
ethnicity (OR=1.455, CI=0.874,
2.42; p=0.149). In conclusion, the MAF of
the FTO rs9939609 SNP was low as in other Asian
populations and there was no evidence for an involvement of this SNP in obesity and obesity-related
traits in this multi-ethnic Malaysian study group.
Keywords: Fat mass and
obesity-associated gene (FTO);
Malaysia; obesity; rs9939609; single nucleotide polymorphism
ABSTRAK
Obesiti
adalah satu penyakit yang disebabkan oleh pelbagai faktor, termasuk genetik,
cara hidup dan persekitaran. Pelbagai polimorfisme nukleotid
tunggal yang biasa dijumpai di dalam satu gen yang baru ditemui, jisim lemak
dan berkaitan obesiti (FTO),
telah dikaitkan dengan berat badan dan jisim lemak manusia. Kajian kaitan
genom-menyeluruh dalam beberapa populasi telah mendapati bahawa FTO polimorfisme gen rs9939609 berkaitan dengan obesiti. Oleh itu,
objektif penyelidikan ini adalah untuk mengkaji kaitan gen jisim lemak dan
berkaitan obesiti (FTO)
polimorfisme rs9939609 dengan obesiti dalam kalangan 324 masyarakat majmuk
Malaysia (98 Melayu, 158 Cina, 68 India) yang menghadiri Klinik Kesihatan
Kampar, Perak. Dengan frekuensi alel A minor (MAF) 0.199, taburan genotip dan
alel adalah berbeza secara signifikan antara kaum (MAF paling tinggi dalam kalangan Melayu), tetapi tidak berkaitan
dengan obesiti, ukuran antropometri dan jantina. Subjek dengan alel A
mempunyai ukuran lilitan pinggang yang marginal tetapi secara signifikannya
lebih tinggi (p=0.015), oleh itu FTO rs9939609
berkaitan dengan obesiti pusat (p=0.034 dari analisis Chi-square; Odds Ratio (OR) 1.680 (CI=1.036,
2.724; p=0.035)) untuk mempunyai obesiti pusat. Namun, kaitan ini dimansuhkan
apabila dilaras dengan umur, jantina dan etnik (OR=1.455, CI=0.874, 2.42; p=0.149). Secara
keseluruhannya, MAF FTO rs9939609 SNP adalah rendah seperti dalam
populasi Asia lain, dan tidak terdapat bukti bahawa
polimorfisme ini terlibat dalam obesiti dan ciri-ciri obesiti dalam kalangan
masyarakat majmuk Malaysia dalam kajian ini.
Kata kunci: Jisim lemak dan berkaitan obesiti (FTO); Malaysia; Obesiti;
rs9939609; polimorfisme nukleotid tunggal
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*Pengarang untuk
surat-menyurat; email: sayyh@utar.edu.my
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