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Curcumin as an Anti-Arthritic Agent in
Collagen-InducedArthritic Sprague-Dawley Rats
(Kurkumin
sebagai Suatu Agen Antiartritik untukTikus Sprague-Dawley yang Mengalami
Artritis Aruhan Kolagen)
A.F. Zahidah
Department of
Biomedicine Science, Faculty of Allied Health Sciences , Universiti
Kebangsaan Malaysia
Jalan Raja Muda Abdul
Aziz, 50300, Kuala Lumpur, Malaysia
O. Faizah, K. Nur Aqilah
& K. Taty Anna*
Department of Anatomy, Faculty
of Medicine, Universiti Kebangsaan Malaysia
Jalan Raja Muda Abdul
Aziz, 50300, Kuala Lumpur, Malaysia
Diserahkan: 16 Mei 2011/Diterima:
2 November 2011
ABSTRACT
Curcuma longa or
turmeric has long been used in traditional medicine by the local population in
Malaysia as an antiinflammatory agent. It has been proven to contain natural
antiarthritic compound called curcumin. Joints abnormality and destruction have
been implicated in the pathogenesis of rheumatoid arthritis (RA) due to
inflammatory reactions. In this study, collagen-induced arthritis (CIA) model
was utilized to study the effects of curcumin on joint inflammation in Sprague-Dawley rats. Body weight
measurement, arthritis score assessment and radiology score assessment were
carried out at specific intervals throughout this study. The results showed
that the mean arthritis and radiology scores for animal groups designated as CIA CurcuminCand CIA CurcuminTwere
significantly lower compared with the negative control (CIA OV) group
respectively. The mean arthritis scores for CIA CurcuminCgroup is
significantly lower compared with CIA CurcuminTgroup but
there is no significant difference in the mean radiology scores between the CIA CurcuminCand CIA CurcuminTgroups.
In conclusion, the oral supplementation of curcumin at the dose of 110
mg/mL/kg/day has a potential to delay and improve joint abnormality and injury
in Sprague-Dawley rats with CIA.
Keywords: Arthritis score;
collagen-induced arthritis; curcumin; radiology score
ABSTRAK
Curkuma longa atau
kunyit telah lama digunakan dalam perubatan tradisi oleh penduduk tempatan di
Malaysia sebagai agen antiinflamasi. Ia terbukti mengandungi agen antiartritik
semula jadi iaitu Kurkumin. Ketaknormalan pada sendi terlibat dalam patogenesis
artritis reumatoid (RA) disebabkan tindak
balas inflamasi. Dalam kajian ini, model artritis aruhan kolagen (CIA) telah
digunakan untuk mengkaji kesan Kurkumin ke atas sendi tikus Sprague-Dawley. Sepanjang penyelidikan
ini, pengukuran berat badan, penilaian skor artritis dan penilaian skor
radiologi dilakukan pada selang masa tertentu. Hasil kajian menunjukkan bahawa
purata skor artritis dan purata skor radiologi bagi kumpulan CIA KurkuminCdan CIA KurkuminTmasing-masing
adalah lebih rendah secara signifikan berbanding kumpulan kawalan negatif (CIA OV). Purata
skor artritis bagi kumpulan CIA KurkuminCadalah
rendah secara signifikan berbanding kumpulan CIA KurkuminTtetapi
tiada perbezaan yang tekal pada purata skor radiologi antara kumpulan CIA KurkuminCberbanding
kumpulan CIA KurkuminT.
Kesimpulannya, suplemen oral kurkumin sebanyak 110 mg/mL/kg/hari berpotensi
memperlahan dan memperbaiki ketaknormalan serta kecederaan pada sendi tikus Sprague-Dawley yang mengalami CIA.
Kata
kunci: Artritis aruhan kolagen; kurkumin; skor artritis; skor radiologi
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* Pengarang
untuk surat-menyurat; email: tatykamarudin@gmail.com
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