Sains Ma1aysiana 25(1): 77-86 (1996)                                                                                                   Sains Hayat/

                                                                                                                                                         Life Sciences

Levels of Malondialdehyde-Related Immune

Reactants in a Lupus Prone Mouse Strain

M. Danial Yahya

Jabatan Mikrobiologi

Universiti Kebangsaan Malaysia

43600 UKM Bangi, Selangor D.E. Malaysia

Chien C. Lung & Yacob L. Pinnas

Dept. of Medicine, Arizona Health Science Center

Tucson, AZ 85724, USA

ABSTRACT

The levels of malondialdehyde (MDA)-specific antibodies in lupus-prone MRL/ lpr mice of different ages were compared to those against DNA. These mice elicited anti-MDA antibodies earlier and in higher levels that anti-DNA antibodies. The levels of immune complexes containing MDA adducts were also higher in these mice when compared to 3 other non-lupus strains. MDA binding to a 100 kDa serum protein was observed in 3 and 5 month old mice. Immune complexes involving anti-MDA antibodies and MDA adducts may represent an additional mechanism that contributes to disease pathogenesis in these mice.

ABSTRAK

Aras antibodi anti-malondialdehida (MDA) dalam mencit MRL/lpr berbeza umur telah dibandingkan dengan aras antibodi anti-DNA. Mencit ini menghasilkan antibodi anti-MDA lebih awal dan pada aras yang lebih tinggi berbanding antibodi anti-DNA. Aras kompleks imun yang mengandungi MDA juga lebih tinggi berbanding aras dalam 3 strain mencit lain. Pergabungan MDA dengan suatu protein serum bersaiz 100 kDa dikesan pada mencit berumur 3 dan 5 bulan. Kompleks imun yang mengandungi MDA dan antibodi anti-MDA mungkin merupakan satu lagi mekanisma yang terlibat dalam patogenesis penyakit lupus pada mencit strain ini.

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