Sains Malaysiana 46(10)(2017): 1877–1886

http://dx.doi.org/10.17576/jsm-2017-4610-26

 

Observation of Tumour-induced Reorganization in Structural and Functional Architecture of the Brain in Three Pre-surgical Patients with Left Frontal-temporal Brain Tumour: A Combination of MEG, DTI and Neuropsychological Assessment

(Pemerhatian Tumor Menyebabkan Perubahan pada Struktur dan Fungsi Otak dalam Tiga Pesakit Pra-pembedahan yang menghidap Tumor Otak pada Bahagian Frontal-Temporal: Kombinasi MEG, DTI dan Penilaian Neuropsikologi)

 

HANANI ABDUL MANAN^1*, ZAMZURI IDRIS^2,3, MOHAMMED FARUQUE REZA³, WAN NOR AZLEN WAN MOHAMAD³ & JAFRI MALIN ABDULLAH²

 

¹Department of Radiology, Pusat Perubatan Universiti Kebangsaan Malaysia, Jalan Yaacob Latif, Bandar Tun Razak, 56000 Cheras, Kuala Lumpur, Federal Territory, Malaysia

 

²Center for Neuroscience Service and Research, School of Medical Sciences, Universiti Sains Malaysia, 16150 Kubang Kerian, Kelantan Darul Naim, Malaysia

 

³Department of Neurosciences, School of Medical Sciences, Universiti Sains Malaysia, 16150 Kubang Kerian, Kelantan Darul Naim, Malaysia

 

 

Received: 3 January 2017/Accepted: 29 September 2017

 

ABSTRACT

Visual function is mainly located within the bilateral hemisphere of the occipital lobes of the brain. However, our functional magnetoencephalography (MEG) result has demonstrated the reorganization of brain activity in the occipital area in patients with left-sided brain tumour. The results showed that brain laterality changes from bilateral to unilateral activation of the occipital area. Right occipital area (contralateral areas to the tumour), shows increase intensity of activation. Diffusion tensor imaging (DTI) with fibre tracking was performed to further investigate this brain laterality modification and the findings confirmed there is an alteration in the left hemisphere fibre optic tracts. This functional modification and changes of the brain laterality and optic tracts in the brain is suspected to be the result of tumour growth induced changes. The present observation will be discussed in term of the mechanism of tumour induced reorganization and changes with the corroborating evidence from MEG, DTI and neuropsychological assessment.

 

Keywords: Diffusion tensor imaging; magnetoencephalography; neuroplasticity; visual evoked field and functional shifted

ABSTRAK

Fungsi visual terletak pada kedua-dua belah bahagian hemisfera lobus osipital. Walau bagaimanapun, hasil kajian kefungsian dengan menggunakan magnetoensefalografi (MEG) menunjukkan berlakunya pengubahsuaian pada pengaktifan otak bagi pesakit yang menghidap tumor pada sebelah kiri otak. Keputusan menunjukkan pengaktifan unilateral pada pesakit tersebut iaitu pada sebelah kontralateral pada bahagian tumor. Keputusan kajian ini turut disokong oleh keputusan daripada pengimejan tensor resapan (DTI). Keputusan daripada pengimejan DTI turut menunjukkan terdapatnya perubahan pada optik fiber pada sebelah kiri hemisfera. Perubahan kefungsian dan perubahan pada optik fiber ini dicadangkan disebabkan oleh tumor. Keputusan pemerhatian ini akan dibincangkan daripada segi makanisme keplastikan neuro dengan menghubungkan bukti daripada pengimejan MEG, DTI dan ujian psikologi.

 

Kata kunci: Keplastikan neuro; magnetoensefalografi; pengimejan tensor resapan; rangsangan medan penglihatan dan kefungsian teranjak

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*Corresponding author; email: hanani@ukm.edu.my